Drontal
Disclaimer: This site has been created by www.MedicAnimal.com for information purposes only. MedicAnimal is a proud retailer of Drontal but is not affiliated with or related to the manufacturer of Drontal and the contents of this site are neither sponsored or endorsed by the manufacturer of Drontal.
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Introduction
1. Drontal Plus Tablets
2. Drontal Cat Tablets
Presentation
1. Drontal Plus Tablets
Drontal Plus Flavour Tablet is a pale brown to brown flavoured tablet containing 50 mg praziquantel, 144 mg pyrantel embonate and 150 mg febantel.
Drontal Plus XL Tablet is a pale yellow tablet containing 175 mg praziquantel, 504 mg pyrantel embonate and 525 mg febantel.
2. Drontal Cat Tablets
Drontal Cat Tablets are coated white to pale yellow tablets each containing 230 mg pyrantel embonate and 20 mg praziquantel
Drontal Cat XL Tablets are coated white to pale yellow tablets each containing 345 mg pyrantel embonate and 30 mg praziquantel.
Uses
1. Drontal Plus Tablets
For the control of the following gastrointestinal tapeworms and roundworms of dogs and puppies.
Ascarids
Toxocara canis, Toxascaris leonina (adult and late immature forms).
Hookworms
Uncinaria stenocephala, Ancylostoma caninum (adults).
Whipworms
Trichuris vulpis (adults).
Tapeworms
Echinococcus species, Taenia species, Dipylidium caninum (adults and immature forms).
2. Drontal Cat Tablets
For the treatment of gastrointestinal roundworms and tapeworms of cats (see also ‘further information’).
Ascarids: | Toxocara cati |
Toxascaris leonina | |
Tapeworm: | Dipylidium caninum |
Taenia taeniaeformis |
Dosage & administration
1. Drontal Plus Tablets
For oral administration only.
The recommended dose rates are: 15 mg/kg bodyweight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel.
1 Drontal Plus Flavour Tablet per 10 kg bodyweight;
1 Drontal Plus XL Tablet per 35 kg bodyweight.
The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment.
Dosage Guide: Puppies and small dogs
½–2 kg bodyweight = ¼ Drontal Plus Flavour Tablet
2–5 kg bodyweight = ½ Drontal Plus Flavour Tablet
6–10 kg bodyweight = 1 Drontal Plus Flavour Tablet
Dosage Guide: Medium dogs
11–15 kg bodyweight = 1½ Drontal Plus Flavour Tablet
16–20 kg bodyweight = 2 Drontal Plus Flavour Tablet
21–25 kg bodyweight = 2½ Drontal Plus Flavour Tablet
26–30 kg bodyweight = 3 Drontal Plus Flavour Tablet
Dosage Guide: Large dogs
31 - 35 kg bodyweight | = 1 tablet Drontal Plus XL |
36 - 40 kg bodyweight | = 1 Drontal Plus XL Tablet plus ½ tablet Drontal Plus Flavour |
41 - 45 kg bodyweight | = 1 Drontal Plus XL Tablet plus 1 tablet Drontal Plus Flavour |
46 - 50 kg bodyweight | = 1 Drontal Plus XL Tablet plus 1½ tablets Drontal Plus Flavour |
51 - 55 kg bodyweight | = 1 Drontal Plus XL Tablet plus 2 tablets Drontal Plus Flavour |
56 - 60 kg bodyweight | = 1 Drontal Plus XL Tablet plus 2½ tablet Drontal Plus |
61 - 65 kg bodyweight | = 1 Drontal Plus XL Tablet plus 3 tablets Drontal Plus Flavour |
66 - 70 kg bodyweight | = 2 Drontal Plus XL Tablets |
For routine treatment a single dose is recommended.
Puppies should be treated at 2 weeks of age and every 2 weeks until 12 weeks of age. Thereafter they should be treated at 3 month intervals. It is advisable to treat the bitch at the same time as the puppies.
For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every two weeks until weaning.
For routine control adult dogs should be treated every 3 months. For routine treatment a single dose is recommended. In the event of heavy roundworm infestation a repeat dose should be given after 14 days.
Use During Pregnancy and Lactation
Consult a veterinary surgeon before treating pregnant animals for roundworms.
The product may be used during lactation.
Do not exceed recommended dose when treating pregnant bitches.
2. Drontal Cat Tablets
Dosage
The recommended dose rates are 57.5 mg/kg pyrantel embonate and 5 mg/kg praziquantel. This is equivalent to one Drontal Cat Tablets per 4 kg bodyweight and 1 Drontal Cat XL Tablets per 6 kg bodyweight.
See dosage chart below for examples:
Weight of Cat | No of Drontal Cat Tablets | No of Drontal Cat XL Tablets | |
up to 2 kg | 0.5 | - | |
> 2 kg up to 4 kg | 1 | - | |
> 4 kg up to 6 kg | - | 1 | |
> 6 kg up to 8 kg | 2 | ||
> 8 kg up to 10 kg | 1 | plus | 1 |
Administration and Duration of Treatment
For single oral administration. The tablets should be given directly to the animal, but if necessary can be disguised in food.
Use During Pregnancy and Lactation
Not to be used during pregnancy but may be used during lactation.
Price comparison
Contra-indications, warnings, etc.
1. Drontal Plus Tablets
Do not use simultaneously with piperazine compounds.
User safety
In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog's food, should wash their hands afterwards.
2. Drontal Cat Tablets
Not intended for use in kittens less than 6 weeks of age.
Do not use simultaneously with piperazine compounds.
Until sufficient studies have been performed with this combination, do not use during pregnancy.
User Safety
In the interests of good hygiene, persons administering the tablets directly to a cat, or by adding them to the cat’s food, should wash their hands afterwards.
For animal treatment only.
Keep out of the reach of children
Environmental Safety
Empty containers or part used product should be disposed of with household refuse.
Unused product should be disposed of in accordance with any guidance from an appropriate waste regulation authority.
Pharmaceutical precautions
1. Drontal Plus Tablets
Do not store above 25°C.
Protect from light.
Do not use after the expiry date.
Any part used tablets should be discarded.
Any unused or waste material should be disposed of in accordance with national requirements.
2. Drontal Cat Tablets
Do not store above 25°C.
Do not remove tablets from strip packing until required for use. Any part-used tablets should be discarded.
Packaging quantities
1. Drontal Plus Tablets
Drontal Plus Flavour Tablets: | Cartons containing 2, 8, 24, and 104 foil blistered tablets. |
Drontal Plus XL Tablets: | Cartons of 2, 10, 20 and 50 foil blistered tablets. |
2. Drontal Cat Tablets
Drontal Cat Tablets: | Cartons containing 2, 20 or 100 in strips of 2 or 10 tablets. |
Drontal Cat XL Tablets: | Cartons containing 2, 10, and 50 tablets in strips of 2 or 10 tablets. |
Further information
1. Drontal Plus Tablets
The product contains anthelmintics active against roundworms and tapeworms. The product contains three active substances: Febantel, Pyrantel embonate (pamoate) and Praziquantel.
Praziquantel is a partially hydrogenated pyrazino-isoquinoline derivative used widely as an anthelmintic for both human and veterinary use.
In this fixed combination pyrantel and febantel act against all relevant nematodes (ascarids, hookworms, and whipworms) in dogs. In particular the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis. This combination shows synergistic activity in the case of hookworms and febantel is effective against T.vulpis.
The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular Taenia spp, Dipylidium caninum, Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against all adult and immature forms of these parasites.
Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis of the nematodes and thereby allow removal from the gastrointestinal system by peristalsis.
Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerization. Formation of microtubules is thereby prevented, resulting in disruption of structures vital to the normal functioning of the helminth. Glucose uptake in particular is affected, leading to a depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.
Praziquantel is very rapidly absorbed through the parasite’s surface and distributed throughout the parasite. Both in vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite integument, resulting in the contraction and paralysis of the parasites. There is an almost instantaneous titanic contraction of the parasite musculature and a rapid vacuolization of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.
Benzimidazoles possess a wide safety margin. Pyrantel is not absorbed systemically to any extent. Praziquantel also has a wide safety margin, beyond five-times overdose.
The product is well tolerated in dogs. In safety studies doses of 5 x or greater gave rise to occasional vomiting.
Since it contains praziquantel, the product is effective against Echinococcus multilocularis, which does not occur in the UK but is becoming more common in some European countries. As a precautionary measure to prevent establishment of E. multilocularis in the UK and Ireland, it is recommended that all dogs entering the country travelling either under the PETS scheme (UK only) or going into quarantine (UK & Ireland) be treated with praziquantel.
Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infestation is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.
2. Drontal Cat Tablets
Drontal® Cat Tablets and Drontal® Cat XL Tablets are an anthelmintic active against roundworms and tapeworms. The product contains two active ingredients, pyrantel embonate (pamoate) and praziquantel. Praziquantel is used widely as an anthelmintic for both human and veterinary use.
Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow expulsion from the gastro-intestinal (GI) system by peristalsis.
Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.
In this fixed combination product, the pyrantel is active against the following ascarids: Toxocara cati, and Toxascaris leonina; the praziquantel is effective against tapeworms, in particular Dipylidium caninum and Taenia taeniaeformis.
The product has been shown to be effective in the control of hookworms Ancylostoma tubaeforme and A. braziliense and the tapeworm Joyeuxiella pasqualei, none of which occur naturally in cats in the UK but may occasionally be found in imported animals.
Praziquantel is effective against Echinococcus multilocularis. E. multilocularis does not occur in the UK but is becoming more common in some European countries. As a precautionary measure to prevent establishment of E. multilocularis in the UK, it is recommended that all cats entering the country be treated with praziquantel.
Fleas serve as intermediate hosts for one common type of tapeworm - Dipylidium caninum. Tapeworm infestation is certain to re-occur unless control of intermediate hosts such as fleas, mice etc. is undertaken.
Disclaimer
This site has been created by www.MedicAnimal.com for information purposes only. MedicAnimal is a proud retailer of Drontal but is not affiliated with or related to the manufacturer of Drontal and the contents of this site are neither sponsored or endorsed by the manufacturer of Drontal.